eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine

HOME
QUERY
- DISEASE
- GENOTYPE
NETWORK
- PHENOTYPE
- GENE
- COMMON
- DISEASE PAIR
DOWNLOAD
SUBMIT CASE
HELP&FAQ
- HELP&FAQ
- CONTACT US


	membranous nephropathy

Disease ID	651
Disease	membranous nephropathy
Definition	A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
Synonym	chronic nephritic syndrome, diffuse membranous glomerulonephritis chronic nephritic syndrome, diffuse membranous glomerulonephritis (disorder) extramembranous glomerulopathy glomerulonephritides, membranous glomerulonephritis membranous glomerulonephritis, membranous glomerulonephritis, membranous [disease/finding] glomerulonephropathy, membranous glomerulopathy, extramembranous glomerulopathy, membranous membranous glomerulonephritides membranous glomerulonephritis membranous glomerulonephritis (disorder) membranous glomerulonephritis nos membranous glomerulonephropathy membranous glomerulopathy membranous nephropathy nos mgn mgn - membranous glomerulonephritis nephropathy, membranous
DOID	DOID:10976
UMLS	C0017665
MeSH	D015433
SNOMED-CT	SNOMEDCT_US_2016_09_01:77182004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:72) C0027726 \| nephrotic syndrome \| 36 C0033687 \| proteinuria \| 9 C0017658 \| glomerulonephritis \| 6 C0027697 \| nephritis \| 6 C0027707 \| interstitial nephritis \| 5 C0019158 \| hepatitis \| 5 C0022658 \| kidney disease \| 4 C0019163 \| hepatitis b \| 4 C0008312 \| biliary cirrhosis \| 3 C0042384 \| vasculitis \| 3 C0024141 \| systemic lupus erythematosus \| 3 C0008312 \| primary biliary cirrhosis \| 3 C0041349 \| tubulointerstitial nephritis \| 3 C0033838 \| kimura's disease \| 2 C0022658 \| renal disease \| 2 C0022661 \| end-stage renal disease \| 2 C1261473 \| sarcoma \| 2 C0022679 \| cystic kidney \| 2 C0041296 \| tuberculosis \| 2 C0024299 \| lymphoma \| 2 C0036220 \| kaposi sarcoma \| 2 C0023890 \| cirrhosis \| 2 C0032027 \| pityriasis rubra pilaris \| 1 C0023448 \| lymphocytic leukemia \| 1 C0007847 \| cervical cancer \| 1 C0206141 \| idiopathic hypereosinophilic syndrome \| 1 C0403529 \| goodpasture's disease \| 1 C0007113 \| rectal cancer \| 1 C0206644 \| fibrous histiocytoma \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0026709 \| mucopolysaccharidosis type vi \| 1 C0393819 \| chronic inflammatory demyelinating polyneuropathy \| 1 C0017668 \| focal segmental glomerulosclerosis \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0221348 \| yellow nail syndrome \| 1 C0009402 \| colorectal cancer \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0026769 \| multiple sclerosis \| 1 C0040053 \| thrombosis \| 1 C0023895 \| liver disease \| 1 C0235618 \| proliferative glomerulonephritis \| 1 C0035078 \| renal failure \| 1 C0409974 \| lupus erythematosus \| 1 C1527336 \| sjogren's syndrome \| 1 C0018378 \| guillain-barre syndrome \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0282193 \| iron overload \| 1 C0041234 \| chagas disease \| 1 C1136085 \| monoclonal gammopathy \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0949691 \| spondyloarthropathy \| 1 C0022661 \| chronic kidney disease \| 1 C0152025 \| polyneuropathy \| 1 C0026703 \| mucopolysaccharidosis \| 1 C0398623 \| hypercoagulable state \| 1 C0349632 \| splenic marginal zone lymphoma \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0178664 \| glomerulosclerosis \| 1 C0017661 \| iga nephropathy \| 1 C0011881 \| diabetic kidney disease \| 1 C0034065 \| pulmonary embolism \| 1 C0524988 \| schnitzler syndrome \| 1 C0021400 \| influenza \| 1 C1565489 \| renal insufficiency \| 1 C1509147 \| histiocytoma \| 1 C0241910 \| autoimmune hepatitis \| 1 C0302592 \| cervical ca \| 1 C0017662 \| membranoproliferative glomerulonephritis \| 1 C0019829 \| hodgkin lymphoma \| 1 C0008728 \| churg-strauss syndrome \| 1 C0039263 \| takayasu's arteritis \| 1 C0023418 \| leukemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 3123 \| HLA-DRB1 \| CTD_human 213 \| ALB \| CTD_human 3117 \| HLA-DQA1 \| CTD_human 335 \| APOA1 \| CTD_human 2548 \| GAA \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) 1286 \| COL4A4 \| CIPHER 3117 \| HLA-DQA1 \| CIPHER;CTD_human 22925 \| PLA2R1 \| CIPHER 213 \| ALB \| CTD_human 2548 \| GAA \| CTD_human 3123 \| HLA-DRB1 \| CTD_human 335 \| APOA1 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:93) 2 \| A2M \| 1.006 \| DISEASES 87 \| ACTN1 \| 1.161 \| DISEASES 88 \| ACTN2 \| 1.248 \| DISEASES 375790 \| AGRN \| 1.795 \| DISEASES 154810 \| AMOTL1 \| 1.944 \| DISEASES 2909 \| ARHGAP35 \| 2.114 \| DISEASES 9181 \| ARHGEF2 \| 1.355 \| DISEASES 567 \| B2M \| 2.82 \| DISEASES 720 \| C4A \| 1.685 \| DISEASES 721 \| C4B \| 1.931 \| DISEASES 930 \| CD19 \| 1.648 \| DISEASES 23607 \| CD2AP \| 1.533 \| DISEASES 959 \| CD40LG \| 4.293 \| DISEASES 960 \| CD44 \| 1.503 \| DISEASES 966 \| CD59 \| 2.287 \| DISEASES 922 \| CD5L \| 1.055 \| DISEASES 55561 \| CDC42BPG \| 3.119 \| DISEASES 629 \| CFB \| 1.879 \| DISEASES 80790 \| CMIP \| 1.525 \| DISEASES 152330 \| CNTN4 \| 1.14 \| DISEASES 1378 \| CR1 \| 1.47 \| DISEASES 286204 \| CRB2 \| 1.61 \| DISEASES 1490 \| CTGF \| 1.331 \| DISEASES 51428 \| DDX41 \| 1.637 \| DISEASES 1668 \| DEFA3 \| 1.039 \| DISEASES 8214 \| DGCR6 \| 1.872 \| DISEASES 50943 \| FOXP3 \| 1.398 \| DISEASES 25801 \| GCA \| 1.157 \| DISEASES 64412 \| GZF1 \| 2.715 \| DISEASES 26762 \| HAVCR1 \| 1.801 \| DISEASES 3105 \| HLA-A \| 2.612 \| DISEASES 3115 \| HLA-DPB1 \| 1.561 \| DISEASES 3117 \| HLA-DQA1 \| 3.965 \| DISEASES 3118 \| HLA-DQA2 \| 4.323 \| DISEASES 3127 \| HLA-DRB5 \| 1.658 \| DISEASES 8091 \| HMGA2 \| 1.358 \| DISEASES 3240 \| HP \| 1.187 \| DISEASES 3309 \| HSPA5 \| 1.331 \| DISEASES 3339 \| HSPG2 \| 1.867 \| DISEASES 3440 \| IFNA2 \| 1.017 \| DISEASES 3321 \| IGSF3 \| 2.327 \| DISEASES 3609 \| ILF3 \| 1.014 \| DISEASES 55243 \| KIRREL \| 1.598 \| DISEASES 284217 \| LAMA1 \| 1.231 \| DISEASES 3949 \| LDLR \| 1.497 \| DISEASES 348801 \| LNP1 \| 1.544 \| DISEASES 4153 \| MBL2 \| 1.912 \| DISEASES 4157 \| MC1R \| 1.861 \| DISEASES 10724 \| MGEA5 \| 2.182 \| DISEASES 8569 \| MKNK1 \| 1.16 \| DISEASES 4311 \| MME \| 3.502 \| DISEASES 5891 \| MOK \| 1.507 \| DISEASES 4868 \| NPHS1 \| 4.456 \| DISEASES 7827 \| NPHS2 \| 3.499 \| DISEASES 255743 \| NPNT \| 2.752 \| DISEASES 4942 \| OAT \| 1.768 \| DISEASES 26578 \| OSTF1 \| 1.983 \| DISEASES 23556 \| PIGN \| 1.772 \| DISEASES 8399 \| PLA2G10 \| 1.134 \| DISEASES 5320 \| PLA2G2A \| 1.824 \| DISEASES 5321 \| PLA2G4A \| 1.989 \| DISEASES 5420 \| PODXL \| 2.953 \| DISEASES 23509 \| POFUT1 \| 1.378 \| DISEASES 28227 \| PPP2R3B \| 1.59 \| DISEASES 387 \| RHOA \| 1.256 \| DISEASES 22908 \| SACM1L \| 1.53 \| DISEASES 6401 \| SELE \| 1.065 \| DISEASES 5265 \| SERPINA1 \| 1.379 \| DISEASES 8710 \| SERPINB7 \| 2.344 \| DISEASES 5271 \| SERPINB8 \| 2.601 \| DISEASES 5272 \| SERPINB9 \| 1.791 \| DISEASES 9748 \| SLK \| 1.037 \| DISEASES 27293 \| SMPDL3B \| 2.103 \| DISEASES 64089 \| SNX16 \| 2.254 \| DISEASES 51429 \| SNX9 \| 1.354 \| DISEASES 6696 \| SPP1 \| 1.05 \| DISEASES 11346 \| SYNPO \| 4.123 \| DISEASES 7018 \| TF \| 2.035 \| DISEASES 7029 \| TFDP2 \| 1.818 \| DISEASES 221981 \| THSD7A \| 5.606 \| DISEASES 84000 \| TMPRSS13 \| 1.38 \| DISEASES 7124 \| TNF \| 1.959 \| DISEASES 51330 \| TNFRSF12A \| 1.389 \| DISEASES 7133 \| TNFRSF1B \| 1.034 \| DISEASES 8718 \| TNFRSF25 \| 3.748 \| DISEASES 8742 \| TNFSF12 \| 1.654 \| DISEASES 80128 \| TRIM46 \| 1.716 \| DISEASES 7225 \| TRPC6 \| 2.303 \| DISEASES 6675 \| UAP1 \| 1.554 \| DISEASES 7335 \| UBE2V1 \| 1.685 \| DISEASES 147179 \| WIPF2 \| 2.003 \| DISEASES 7490 \| WT1 \| 1.463 \| DISEASES 162239 \| ZFP1 \| 1.559 \| DISEASES
Locus	(Waiting for update.)

Disease ID	651
Disease	membranous nephropathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:44) HP:0000100 \| Nephrosis \| 36 HP:0000093 \| Proteinuria \| 10 HP:0000123 \| Nephritis \| 8 HP:0000099 \| Glomerular nephritis \| 6 HP:0012115 \| Liver inflammation \| 5 HP:0001970 \| Interstitial nephritis \| 5 HP:0002725 \| Systemic lupus erythematosus \| 3 HP:0002613 \| Biliary cirrhosis \| 3 HP:0002633 \| Vasculitis \| 3 HP:0001907 \| Thromboembolic disease \| 3 HP:0000083 \| Renal insufficiency \| 2 HP:0100242 \| Sarcoma \| 2 HP:0200123 \| Chronic liver inflammation \| 2 HP:0012574 \| Mesangial hypercellularity \| 2 HP:0002665 \| Lymphoma \| 2 HP:0001394 \| Hepatic cirrhosis \| 2 HP:0012189 \| Hodgkin disease \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0000113 \| Polycystic kidney dysplasia \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0004319 \| Mineralocorticoid insufficiency \| 1 HP:0001909 \| Leukemia \| 1 HP:0000097 \| focal glomerulosclerosis \| 1 HP:0012315 \| Histiocytoma \| 1 HP:0003073 \| Hypoalbuminaemia \| 1 HP:0001941 \| acidemia \| 1 HP:0012597 \| Heavy proteinuria \| 1 HP:0200120 \| Chronic active hepatitis \| 1 HP:0000127 \| Salt wasting \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0002720 \| Decreased immunoglobulin A \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0002664 \| Neoplasia \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0012593 \| Nephrotic range proteinuria \| 1 HP:0000793 \| Membranoproliferative glomerulonephritis \| 1 HP:0012588 \| Steroid-resistant nephrotic syndrome \| 1 HP:0006532 \| Pneumonia, recurrent episodes \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0000096 \| Glomerulosclerosis \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0002204 \| Pulmonary embolism \| 1

Disease ID	651
Disease	membranous nephropathy
Manually Symptom	UMLS \| Name(Total Manually Symptoms:35) C2697391 \| rheumatoid arthritis C2697310 \| sarcoidosis C2677535 \| ane syndrome C1963154 \| renal failure C1962974 \| chylothorax C1962972 \| proteinuria C1561644 \| chronic kidney disease (ckd) C1417247 \| glomerulosclerosis C1318533 \| secondary polycythemia C0949691 \| spondyloarthropathy C0850666 \| helicobacter pylori infection C0566602 \| primary sclerosing cholangitis C0521607 \| peritoneal fibrosis C0403416 \| crescentic glomerulonephritis C0268750 \| necrotizing glomerulonephritis C0265050 \| vena cava thrombosis C0238457 \| renal vein thrombosis C0221013 \| systemic mastocytosis C0206669 \| liver cell adenoma C0162678 \| neurofibromatosis C0162557 \| acute hepatic failure C0149678 \| epstein-barr virus infection C0041327 \| pulmonary tuberculosis C0041296 \| tuberculosis C0040053 \| thrombosis C0032461 \| polycythaemia C0030805 \| bullous pemphigoid C0027831 \| recklinghausen's neurofibromatosis C0027726 \| nephrotic syndrome C0027697 \| nephritis C0022661 \| end-stage renal disease C0022661 \| chronic renal failure C0017531 \| angiolymphoid hyperplasia C0015624 \| fanconi's syndrome C0011633 \| dermatomyositis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:11) C0027726 \| nephrotic syndrome \| 36 C0033687 \| proteinuria \| 10 C0027697 \| nephritis \| 7 C0022661 \| end-stage renal disease \| 2 C0034065 \| pulmonary embolism \| 1 C0035078 \| renal failure \| 1 C0041296 \| tuberculosis \| 1 C0178664 \| glomerulosclerosis \| 1 C0949691 \| spondyloarthropathy \| 1 C0206141 \| idiopathic hypereosinophilic syndrome \| 1 C0268750 \| necrotizing glomerulonephritis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs397507444	21500982	4524	MTHFR	umls:C0017665	BeFree	Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase A1298C mutation in adult membranous glomerulonephritis.	0.000542884	2011	MTHFR	1	11794407	T	G
rs397507444	21500982	2153	F5	umls:C0017665	BeFree	Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase A1298C mutation in adult membranous glomerulonephritis.	0.000542884	2011	MTHFR	1	11794407	T	G
rs4664308	21323541	22925	PLA2R1	umls:C0017665	GAD	[An HLA-DQA1 allele on chromosome 6p21 is most closely associated with idiopathic membranous nephropathy in persons of white ancestry. This allele may facilitate an autoimmune response against targets such as variants of PLA2R1. Our findings suggest a basi]	0.006905599	2011	PLA2R1;LOC105373717	2	160060986	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:2)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
2	160917497	rs4664308	A	G	rs4664308	21323541	9.00E-29	NA	2.28	[1.96-2.64]	556 European ancestry cases; 2,338 European ancestry controls	European(2894)	ALL(2894)	EUR(2894)	ALL(2894)	Nephropathy (idiopathic membranous)	HPOID:0000112	Nephropathy	DOID:10976	membranous glomerulonephritis	D015433	Glomerulonephritis, Membranous	EFOID:0004254	membranous glomerulonephritis	Glomerulonephritis	NA	Research Support, Non-U.S. Gov't	A	PLA2R1
6	32605884	rs2187668	C	T	rs2187668	21323541	8.00E-93	NA	4.32	[3.73-5.01]	556 European ancestry cases; 2,338 European ancestry controls	European(2894)	ALL(2894)	EUR(2894)	ALL(2894)	Nephropathy (idiopathic membranous)	HPOID:0000112	Nephropathy	DOID:10976	membranous glomerulonephritis	D015433	Glomerulonephritis, Membranous	EFOID:0004254	membranous glomerulonephritis	Glomerulonephritis	NA	Research Support, Non-U.S. Gov't	G	HLA-DQA1

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	651
Disease	membranous nephropathy
Case	(Waiting for update.)

Web Analytics Made Easy - StatCounter